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But when I, and you I'm positive, get a cold sore, I want to get rid of it as rapidly and painlessly as attainable. The exception to the rule is the DOT1 family, members of which methylate K79 within the globular area of histone H3 and that are structurally not related to SET-area proteins four - 6 Recent work means that SET-domain-containing proteins methylate a few proteins in addition to histones (see later)