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As an example, human SET7/9 has just lately been reported to methylate Lys189 in the basic transcription factor TAF10, leading to an elevated affinity for RNA polymerase II and transcriptional activation of sure TAF10-dependent genes 37 SET7/9 has also been reported to methylate p53, growing the soundness of this quick lived tumor-suppressor protein 38 These observations counsel that we must always not narrowly define the SET-domain proteins as histone lysine methyltransferases however instead call them protein lysine methyltransferases. |
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